Chronic Psychitis

A clear, numerate survey of the inflammatory-cytokine hypothesis of depression (Dantzer et al on sickness-behavior; IL-1b/TNF-a; the suspicious-facts list -- exercise/diet/sleep, stress, the SSRI anti-cytokine effect, the depression<->heart-disease and cancer/inflammation links, the IDO->kynurenine pathway, cytokine-treatment-induced depression). Counterweighted by strong epistemic humility: the effect is wishy-washy, and 'it's very easy to get lots of convincing evidence for a theory in medicine whether or not it's true' (the serotonin and BDNF theories each looked airtight and faded). Closes with a Fermi estimate that switching depressed patients to celecoxib would cause ~50,000 extra heart attacks/year, so the practical advice stays diet/sleep/exercise.

Quality 70 · Strong. A competent, well-hedged medical explainer whose best move is the meta-skeptical frame (medicine manufactures convincing evidence for false theories) plus the celecoxib risk calculation. Solidly Strong, but it surveys others' work rather than contributing an original model, and is early/short. Held at 70.

Claude’s paradigm shift 50 · Moderate. The inflammation hypothesis is borrowed, not Scott's; the meta-point about medicine's evidentiary promiscuity is a nice but recurring frame. Moderate novelty.

Real-world impact 2 · Minor. Within-discourse explainer; no policy/practice change. Small/within-blog influence.