Highlights From The Comments On Missing Heritability
Read the original on Astral Codex Ten →
Follows up on
↳ Missing Heritability: Much More Than You Wanted To Know — MMTYWTK · Jun 2025
Summary
An exceptionally substantive companion to the Missing-Heritability MMTYWTK: extended technical exchanges with named experts (Sasha Gusev on GxE interactions + the Piffer cross-ancestry-polygenic-score critique; Eric Turkheimer on DGE heritability), the non-additive-genetics debate (Steve Byrnes' traits-map-nonlinearly-to-outcomes model; the sports-injury toy example), the Illumina-short-read-vs-long-read sequencing blind spot, and assortative-mating corrections — with Scott's sharp counter-questions throughout.
Why this score
Quality 73 · Strong. Top of the companion band: unusually rich, genuinely advancing a live scientific debate with real expert dialogue; capped below the 81 parent (ACX-715).
Claude’s paradigm shift 50 · Moderate. Notable: structures and pressure-tests the competing explanations for the heritability gap.
Real-world impact 2 · Minor. Within-discourse companion on a contested science topic; no material effect. =2.