Scott Alexander, curated
← Back to curation

Obscure Pregnancy Interventions: Much More Than You Wanted To Know

Quality
81
Excellent
Claude Shift
54
Moderate
RWI
3
of 10

Summary

A replication-crisis-aware sequel to the 2012 Biodeterminist's Guide To Parenting, tiering obscure prenatal interventions by evidence: stress/CMV-toxo/embryo-selection (Tier 1), choline [the actionable standout — ~930mg, undersupplied] + licorice + Tylenol (Tier 2), fish [w/ the original fish-are-good-because-of-choline hypothesis], air filter, high-fruit/carotenoids, birth-month, fluoride, plastics, vitamin D, paternal age, abdominal decompression (Tier 3-4). Rigorous confounder-vs-causal reasoning throughout (poverty, genetics, colorism), honest %-true/%-relevant/IQ-equiv estimates, and an explicit mea culpa that his 2012 self (17-IQ-point claim) was over-credulous (now ~2).

Why this score

Quality 81 · Excellent. High-Excellent: comprehensive, actionable, and a model of replication-awareness; one of his stronger MMTYWTKs, comparable to the Lockdown MMTYWTK (82). Docked one below for the inherent speculativeness he flags.

Claude’s paradigm shift 54 · Moderate. Major-shift-adjacent: the tiered/actionable framing + the choline emphasis + the novel fish->choline hypothesis are a fresh synthesis of a scattered literature.

Real-world impact 3 · Moderate. Actionable prenatal advice with real reach in the rationalist/pronatalist community (choline + embryo-selection influenced actual decisions); within-discourse but concretely acted-on. =3.