Drug Users Use A Lot Of Drugs

Scott's clarification that recreational drug users take doses orders of magnitude higher than psychiatric patients, so the scary side effects come from recreational doses, not clinical ones: ketamine bladder injury appears at ~90,000 mg/month (recreational) not ~280 mg/month (psych); meth (~1000 mg-equivalent) vs Adderall (20 mg); the amphetamine-cardiovascular-aging study used polysubstance abusers at ~50x clinical doses. Clinical risk should be judged on clinical-population studies.

Quality 68 · Strong. A clean, genuinely useful clarification that corrects a common error (extrapolating recreational-user studies to clinical patients) - the dose difference is so large that recreational and clinical use are 'basically two different chemicals,' well-illustrated with concrete numbers. The kind of 'does the work nobody else did' clarity; Strong, brief.

Claude’s paradigm shift 48 · Moderate. Moderate - the recreational-vs-clinical-dose reframe is a fresh, clarifying point.

Real-world impact 2 · Minor. 2 - practically useful clinical clarification; within-discourse.